Migraines Appear More Likely To Be Caused By Histamine Rather Than Ethanol

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Schnedl WJ1Queissner R2. Eur J Neurol. 

2019 May 20. doi: 10.1111/ene.14003. [Epub ahead of print]

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1 General Internal Medicine Practice, Dr. Theodor Körnerstrasse 19b, 8600, Bruck, Austria.

2 Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Auenbruggerplatz 36, 8036, Graz, Austria.



We read with interest the manuscript by Onderwater et al. that reported on alcoholic beverages as a trigger factor for migraines [1]. Although, epidemiological studies have found a correlation between alcohol intake and headaches, a specific pathophysiologic mechanism of this headache remains unidentified [2]. Particularly red wine was documented as the most common trigger for migraines in this evaluated population [1]. Most commonly found biogenic amines in wine – histamine, tyramine, phenylethylamine, putrescine, cadaverine, spermidine, serotonin, tryptamine, agmatine – and, flavonoids have suspected relevance for migraines and this implies that ethanol seems not to be the main culprit for the headaches [2]. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.



Alcohol; Diamine oxidase; Headache; Histamine intolerance; MigrainePMID: 31106460 DOI: 10.1111/ene.14003

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