International Society of DAO Deficiency promotes the progress of science and industry in favour of the population affected by this metabolic disorder.

The Society is composed of three Committees

Their fundamental mission is to collaborate and advice the Society`s Board of directors to ensure better delivery of its activities and work plans, allowing the generation of knowledge, innovation and health benefits.

Them are integrated by experts belonging to clinical, assistential and research groups, enterprises and patient associations. These represent the interaction between the worlds of science, industry and society, respectively.

We have to be aware that a huge percentaje of world population is affected of adverse symptoms related to the effects of diet and how properly works gut metabolism.

What is DAO deficiency?

The decrease in the Diamine Oxidase enzime activity, which metabolize the histamine adquired from diet, triggers it absortion and acumulation in tissues and organs, producing many adverse symptons in the organism.

 

To have an optimal activity of the enzyme Diamine Oxidase is vital in order to histamine does not produce all this variety of symptoms:
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World population affected of migraine
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Rate of people with DAO deficiency and also affected of migraine
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Estimated number of people with migraine and DAO deficiency

Origin of DAO deficiency

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Estimated number of people with fibromyalgia and DAO deficiency
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Rate of people with DAO deficiency and also affected of fibromyalgia
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Global prevalence of fibromyalgia

What is histamine?

Histamine is a molecule derived form an essential amino acid, histidine, and it is produced by decarboxylation through the L-histidine decarboxylase enzyme activity.

Histamine has many physiological and phato-physiological functions.

Know more about histamine

Histamine presence in Food

Histamine is present in many types of food and with different concentrations. It is important to take care on the diet if someone is affected of Diamino Oxidase deficiency, because the consumption of food with high concentrations of histamine can trigger many types of adverse symptoms.

Know more about histamine in food

Food which interferes in histamine metabolism

Some types of Food can generate molecules that block or inhibit the Diamino Oxidase activity.
It is important to know them and design a beneficial diet reducing and/or managing the presence of this types of food, even more if you are diagnosticated of Diamine Oxidase deficiency.

Know more about Food which interferes in histamine metabolism
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World population affected by Irritable bowel syndrome
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Estimated number of people with Irritable bowel syndrome and DAO deficiency
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Rate of people with DAO deficiency and also affected of Irritable bowel syndrome

R&D in DAO deficiency

A recopilation of Scientific articles and Research&Development works about Diamine Oxidase deficiency.

Discover the science behind dao deficiency
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Rate of people with DAO deficiency and also affected of ADHD
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World population affected by ADHD
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Estimated number of people with ADHD and DAO deficiency

Noticias

Nutrición y dietética clínica 3rd Edition
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Nutrición y dietética clínica 3rd Edition Editors: Jordi Salas-Salvadó Paperback ISBN: 9788445823774 eBook ISBN: 9788445825136 Imprint: Elsevier Masson Published Date: 23rd July 2014 Page Count: 696 Description La nueva edición de Nutrición y Dietética Clínica pretende ser una obra de referencia de habla hispana en cuanto al tratamiento dietético permanentemente actualizado de las enfermedades más estrechamente relacionadas con la alimentación y la…

Effects of histamine and diamine oxidase activities on pregnancy: a critical review.
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Effects of histamine and diamine oxidase activities on pregnancy: a critical review. Maintz L1, Schwarzer V, Bieber T, van der Ven K, Novak N. 1 Department of Dermatology and Allergology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Hum Reprod Update. 2008 Sep-Oct;14(5):485-95. PMID: 18499706 DOI: 10.1093/humupd/dmn014 Abstract BACKGROUND: Histamine has been assumed to contribute to embryo-uterine interactions due to…

Histamine-N-methyl transferase polymorphism and risk for migraine
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Histamine-N-methyl transferase polymorphism and risk for migraine. García-Martín E1, Martínez C, Benito-León J, Calleja P, Díaz-Sánchez M, Pisa D, Alonso-Navarro H, Ayuso-Peralta L, Torrecilla D, Agúndez JA, Jiménez-Jiménez FJ. 1 Biochemistry-Molecular Biology Department, University of Extremadura, Badajoz, Spain. Eur J Neurol. 2010 Feb;17(2):335-8. DOI: 10.1111/j.1468-1331.2009.02720.x   Abstract BACKGROUND: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of…

Histamine and histamine intolerance
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Histamine and histamine intolerance  Laura Maintz, Natalija Novak Department of Dermatology, University of Bonn, Bonn, Germany The American Journal of Clinical Nutrition, Volume 85, Issue 5, 1 May 2007, Pages 1185–1196, DOI: https://doi.org/10.1093/ajcn/85.5.1185   Abstract Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs…

Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema
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Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema Maintz L1, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N. 1. Department of Dermatology, University of Bonn, Germany. J Allergy Clin Immunol. 2006 May;117(5):1106-12. Epub 2006 Feb 8. PMID: 16675339 DOI: 10.1016/j.jaci.2005.11.041 Abstract BACKGROUND: A diminished histamine degradation based on a reduced diaminoxidase activity…

The diet factor in pediatric and adolescent migraine
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Millichap, J.Gordon et al. Division of Neurology, Children’s Memorial Hospital, Chicago, Illinois 60614, USA. Pediatr Neurol. 2003 Jan;28(1):9-15. PMID: 12657413 DOI: https://doi.org/10.1016/S0887-8994(02)00466-6 Abstract Diet can play an important role in the precipitation of headaches in children and adolescents with migraine. The diet factor in pediatric migraine is frequently neglected in favor of preventive drug therapy. The list…