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International Society of DAO Deficiency promotes the progress of science and industry in favour of the population affected by this metabolic disorder.

Become a member of the Society is free and it allows you to get access to scientific publications on the field of DAO Deficiency, get access to the member directory of the Society and be able to get in touch with them, and also get passes for events and activities.

To become a member of any of our three committees before you must be associated in one of the member areas of the Society and subsequently send a request for admission to one of them, it will e reviewed and granted by the Board of Directors.

The Society is composed of three Committees

Their fundamental mission is to collaborate and advice the Society`s Board of directors to ensure better delivery of its activities and work plans, allowing the generation of knowledge, innovation and health benefits.

Our committees are integrated by experts belonging to clinical, assistential and research groups, enterprises and patient associations. These represent the interaction between the worlds of science, industry and society, respectively.

We must be aware of the large percentage of the world’s population that is affected by adverse symptoms related to the effects of diet and with alterations in the functioning of the intestinal metabolism.
Migraine
1.050 million people affected by migraine
12%
Irritable Bowel Syndrome: 611 million people affected
7.1%
ADHD: 388 million people affected
2.1%
Fibromyalgia: 124 million people affected

What is DAO deficiency?

The decrease in the Diamine Oxidase enzime activity, which metabolize the histamine adquired from diet, triggers it absortion and acumulation in tissues and organs, producing many adverse symptons in the organism:

 

symptoms dao deficiency
Have an optimal activity of the enzyme diamine oxidase is vital for histamine does not produce all this variety of symptoms.
dao and histamine dao deficiency
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World population affected of migraine
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Rate of people with DAO deficiency and also affected of migraine
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Estimated number of people with migraine and DAO deficiency

Origin of DAO deficiency

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Estimated number of people with fibromyalgia and DAO deficiency
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Rate of people with DAO deficiency and also affected of fibromyalgia
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Global prevalence of fibromyalgia

What is histamine?

Histamine is a molecule derived form an essential amino acid, histidine, and it is produced by decarboxylation through the L-histidine decarboxylase enzyme activity.

Histamine has many physiological and phato-physiological functions.

Know more about histamine

Histamine presence in Food

Histamine is present in many types of food and with different concentrations. It is important to take care on the diet if someone is affected of Diamino Oxidase deficiency, because the consumption of food with high concentrations of histamine can trigger many types of adverse symptoms.

Know more about histamine in food

Food which interferes in histamine metabolism

Some types of Food can generate molecules that block or inhibit the Diamino Oxidase activity.
It is important to know them and design a beneficial diet reducing and/or managing the presence of this types of food, even more if you are diagnosticated of Diamine Oxidase deficiency.

Know more about Food which interferes in histamine metabolism
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World population affected by Irritable bowel syndrome
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Estimated number of people with Irritable bowel syndrome and DAO deficiency
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Rate of people with DAO deficiency and also affected of Irritable bowel syndrome

R&D in DAO deficiency

A recopilation of Scientific articles and Research&Development works about Diamine Oxidase deficiency.

Discover the science behind dao deficiency
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Rate of people with DAO deficiency and also affected of ADHD
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World population affected by ADHD
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Estimated number of people with ADHD and DAO deficiency

Become a member of the Society is free and it allows you to get access to scientific publications on the field of DAO Deficiency, get access to the member directory of the Society and be able to get in touch with them, and also get passes for events and activities.

To become a member of any of our three committees before you must be associated in one of the member areas of the Society and subsequently send a request for admission to one of them, it will e reviewed and granted by the Board of Directors.

News

Association of Diamine oxidase (DAO) variants with the risk for migraine
Association of Diamine oxidase (DAO) variants with the risk for migraine from North Indian population
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Association of Diamine oxidase (DAO) variants with the risk for migraine from North Indian population Dowload pdf Sukhvinder Kaura,⁎, Arif Alib, Yaser Siahbalaeic, Uzair Ahmadc, Fazila Nargisc, A.K. Pandeyd, Balkirat Singhe a UGC-PDF, Gene Expression Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, India b UGC-BSR-FF, Department of Biosciences, Jamia Millia Islamia, New Delhi,…

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Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients
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Dowload pdf Aneta Wagner1, Krzysztof Buczyłko2, Hanna Zielińska-Bliźniewska1, Waldemar Wagner3 1Allergology and Respiratory Rehabilitation Department, Medical University of Lodz, Lodz, Poland 2NZOZ Allergology Center, Lodz, Poland 3Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland Adv Dermatol Allergol 2019; XXXVI (5): 538–543 DOI: https://doi.org/10.5114/ada.2019.89504 Abstract Introduction: Histamine is the major mediator…

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¿What is the DAO deficiency, which is the role of the histamine and which treatments exist? Interview to Dr. Pedro Ojeda
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Dr. Pedro Ojeda, Coodirector of Ojeda’s Clinic of Asthma and Allergy, and member of the International Society of DAO deficiency, tells us about the nature of DAO deficiency, the symptoms of this metabolic disorder, the role of histamine in the body and the treatments available today for its management and prevention. Dr. Pedro Ojeda begins…

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¿How is it diagnosed the DAO deficiency? Interview to Dr. Eva Ruiz
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The DAO deficiency is an alteration in the metabolism of food histamine that occurs when there is low activity of the enzyme diamine oxidase (DAO). This situation occurs when, for different genetic, pharmacological and/or pathological factors, creates a considerable deficiency in the functional activity of this enzyme. In this video, the technical director of GENYCA-Diagnostic…

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