Origin of DAO Deficiency

The main cause of the enzymatic dysfunction of Diamine Oxidase (DAO), called DAO deficiency, which triggers the accumulation of exogenous histamine in tissues and organs has mainly a genetic origin.

Some people have or produce few Diamine Oxidase, this is reason why until recently several chronic pathologies, such as migraine, were believed to be hereditary, when in fact, the hereditary factor is the deficiency of DAO.

Other causes may have their origin in drugs or other pathologies.