{"id":10953,"date":"2022-04-23T10:59:25","date_gmt":"2022-04-23T10:59:25","guid":{"rendered":"https:\/\/www.deficitdao.org\/2022\/04\/23\/disbiosis-intestinal-en-pacientes-con-intolerancia-a-la-histamina\/"},"modified":"2025-07-16T20:42:47","modified_gmt":"2025-07-16T20:42:47","slug":"intestinal-dysbiosis-in-patients-with-histamine-intolerance","status":"publish","type":"post","link":"https:\/\/www.deficitdao.org\/en\/2022\/04\/23\/intestinal-dysbiosis-in-patients-with-histamine-intolerance\/","title":{"rendered":"Intestinal Dysbiosis in Patients with Histamine Intolerance"},"content":{"rendered":"

New study published about microbiota, histamine intolerance and DAO deficiency by the research team of the University of Barcelona (Dr. M\u00aa Carmen Vidal). Adding clinical and scientific evidence every day.<\/p>\n

Download the paper through<\/strong> here<\/strong><\/a><\/p>\n

Abstract:\u00a0<\/strong>An underlying cause of histamine intolerance is diamine oxidase (DAO) deficiency, which leads to defective homeostasis and a higher systemic absorption of histamine. Impaired DAO activity may have a genetic, pharmacological or pathological origin. A recent proposal also suggests it can arise from an alteration in the gut microbiota, although only one study has explored this hypothesis to date. A greater abundance of histamine-secreting bacteria in the gut could lead to the development of histamine\u00a0 ntolerance. Thus, the aim of this study was to characterize the composition of the intestinal microbiota of patients with histamine intolerance symptoms and compare it with that of healthy individuals. The study was performed by sequencing bacterial 16S rRNA genes (V3-V4 region) and analyzing the data using the EzBioCloud Database. Dysbiosis of the gut microbiota was observed in the histamine intolerance group who, in comparison with the healthy individuals, had a significantly lower proportion of Prevotellaceae, Ruminococcus, Faecalibacterium and Faecablibacterium prausnitzii, which are bacteria related to gut health. They also had a significantly higher abundance of histaminesecreting bacteria, including the genera Staphylococcus and Proteus, several unidentified genera belonging to the family Enterobacteriaceae and the species Clostridium perfringens and Enterococcus faecalis. A greater abundance of histaminogenic bacteria would favor the accumulation of high levels of histamine in the gut, its subsequent absorption in plasma and the appearance of adverse effects, even in individuals without DAO deficiency.<\/p>\n

S\u00f2nia S\u00e1nchez-P\u00e9rez 1,2,3 , Oriol Comas-Bast\u00e9 1,2,3 , Adriana Duelo 1,2,3, M. Teresa Veciana-Nogu\u00e9s 1,2,3 ,
\nMercedes Berlanga 4 , M. Luz Latorre-Moratalla 1,2,3,\u2020 and M. Carmen Vidal-Carou 1,2,3,*,\u2020<\/p>\n

1 Department de Nutrici\u00f3, Ci\u00e8ncies de l\u2019Alimentaci\u00f3 i Gastronom\u00eda, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Campus de l\u2019Alimentaci\u00f3 de Torribera, Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain; soniasanchezperez@ub.edu (S.S.-P.); oriolcomas@ub.edu (O.C.-B.);
\naduelo@ub.edu (A.D.); veciana@ub.edu (M.T.V.-N.); mariluzlatorre@ub.edu (M.L.L.-M.)
\n2 Institut de Recerca en Nutrici\u00f3 i Seguretat Aliment\u00e0ria (INSA\u0001UB), Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain
\n3 Xarxa d\u2019Innovaci\u00f3 Aliment\u00e0ria (XIA), C\/Baldiri Reixac 4, 08028 Barcelona, Spain
\n4 Departament de Biologia, Sanitat i Mediambient, Secci\u00f3 de Microbiologia, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona (UB), Av. Joan XXIII 27-31, 08028 Barcelona, Spain; mberlanga@ub.edu<\/p>\n