{"id":7678,"date":"2018-11-29T10:55:12","date_gmt":"2018-11-29T10:55:12","guid":{"rendered":"https:\/\/www.deficitdao.org\/que-es\/"},"modified":"2019-01-11T19:01:04","modified_gmt":"2019-01-11T19:01:04","slug":"what-is","status":"publish","type":"page","link":"https:\/\/www.deficitdao.org\/en\/dao-deficiency\/what-is\/","title":{"rendered":"What is DAO deficiency?"},"content":{"rendered":"

[vc_row heading_color=”light” bg_type=”hosted_video” bg_video_type=”normal” bg_video_device=”yes” header_feature=”yes” bg_video_mp4=”https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/11\/Atoms-5205-1.mp4″ padding_top=”150″ padding_bottom=”150″][vc_column width=”1\/2″]

What is DAO deficiency?<\/span><\/h1>[\/vc_column][vc_column width=”1\/2″]
\"\"<\/div>[\/vc_column][\/vc_row][vc_row heading_color=”dark” bg_type=”image” bg_image=”5856″ bg_image_type=”parallax” header_feature=”yes” footer_feature=”yes” padding_top=”150″ font_color=”#000000″][vc_column width=”2\/3″][vc_column_text css=”.vc_custom_1545402122430{margin-bottom: 30px !important;padding-top: 30px !important;padding-right: 30px !important;padding-bottom: 30px !important;padding-left: 30px !important;background-image: url(https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/12\/blanco-al-61.png?id=8864) !important;border-radius: 35px !important;}”]DAO Deficiency<\/strong>\u00a0is an alteration in the metabolism of food histamine that appears when Diamine Oxidase (DAO) enzyme activity is low. In other words, when for some reason there is a significant deficiency in the functional activity of the main enzyme in the metabolism of histamine.<\/p>\n

The\u00a0imbalance between ingested histamine and the histamine released from the histamine storage cells<\/strong>, and the capacity for histamine degradation, leads to histamine accumulation in plasma. It triggers the occurrence of adverse effects on health.[\/vc_column_text]

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Discover the origin of the DAO deficiency<\/span><\/a><\/div>

Adverse effects of DAO Deficiency<\/span><\/h3>[vc_column_text css=”.vc_custom_1545402528572{padding-top: 30px !important;padding-right: 30px !important;padding-bottom: 30px !important;padding-left: 30px !important;background-image: url(https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/12\/blanco-al-61.png?id=8864) !important;border-radius: 35px !important;}”]<\/p>\n
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In healthy people,<\/strong> histamine taken with food is degraded quickly by Diamine Oxidase (DAO) enzyme, but people with low functional DAO activity have the risk of suffering histamine intolerance or food histaminosis.<\/p>\n

Unlike food allergy, the occurrence of symptoms or adverse effects<\/strong> is not linked to the intake of specific food; not only can it be related to a wide variety of food with different histamine contents, symptoms can also occur even after the ingestion of products with low histamine levels. This imposed considerable difficulty when establishing a maximum tolerable dose; in fact, there is no clear consensus on this value.<\/p>\n

Values that range from 50mg of histamine<\/strong> (in one serving of wine, 125ml, for example) to 60-75mg, prior pure histamine administration, have been listed as triggers of DAO Deficiency symptoms.<\/strong><\/p>\n<\/div>\n

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\"adverse<\/div>[vc_column_text css=”.vc_custom_1545402561532{padding-top: 30px !important;padding-right: 30px !important;padding-bottom: 30px !important;padding-left: 30px !important;background-image: url(https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/12\/blanco-al-61.png?id=8864) !important;border-radius: 35px !important;}”]Due to the wide variety of symptoms derived from DAO Deficiency, which represent chronic pathologies with a high prevalence in population, immediate research and advances on its origin and possible treatments are required.<\/p>\n

It is not necessary for all symptoms to manifest, although most patients with low functional DAO activity present an average of three of those symptoms, being migraine the prevalent one.<\/p>\n

20% of patients experience 1 or 2 of these associated symptoms, 41.3% of patients experience 3 or 4 of these symptoms and 33.8% present more than 5.<\/strong>[\/vc_column_text]

The most frequent symptoms derived from DAO Deficiency<\/span><\/h3>[vc_column_text css=”.vc_custom_1545402443146{margin-bottom: 50px !important;padding-top: 30px !important;padding-right: 30px !important;padding-bottom: 30px !important;padding-left: 30px !important;background-image: url(https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/12\/blanco-al-61.png?id=8864) !important;border-radius: 35px !important;}”]<\/p>\n

Migraine and other vascular headaches.<\/p>\n

Gastrointestinal disorders, especially those associated with irritable bowel syndrome, such as constipation, diarrhea, satiety, flatulence or swollen feeling.<\/p>\n

Dermatological disorders such as dry skin, atopy or psoriasis.<\/p>\n

Soft-tissue pains usually diagnosed as fibromyalgia<\/p>\n

Chronic fatigue<\/p>\n

In childhood and adolescence, DAO deficiency has been linked to attention deficit and hyperactivity disorder (ADHD).<\/p>\n

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Histamine route within the organism<\/span><\/h3>[vc_column_text css=”.vc_custom_1545402597898{padding-top: 30px !important;padding-right: 30px !important;padding-bottom: 30px !important;padding-left: 30px !important;background-image: url(https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/12\/blanco-al-61.png?id=8864) !important;border-radius: 35px !important;}”]In the metabolism of histamine<\/strong>, when it should be degraded by DAO enzyme in order to become N-acetyl aldehyde imidazole, an accumulation of the amine is produced due to the lack of enzyme in the intestinal mucosa cells.<\/strong> Low enzyme activity causes the concentration of histamine, which comes from the food and is generally considered normal, not to be metabolized and a transepithelial permeation of exogenous histamine occurs.<\/p>\n

This way, histamine enters the bloodstream increasing its plasma concentration and once located in blood it spreads throughout the body.[\/vc_column_text][vc_row_inner css=”.vc_custom_1545402750326{margin-bottom: 20px !important;padding-top: 20px !important;padding-right: 20px !important;padding-bottom: 20px !important;padding-left: 20px !important;background-color: #ffffff !important;border-radius: 35px !important;}”][vc_column_inner]

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Know more about histamine<\/span><\/a><\/div>[\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1545402885753{padding-top: 30px !important;padding-right: 30px !important;padding-bottom: 30px !important;padding-left: 30px !important;background-image: url(https:\/\/www.deficitdao.org\/wp-content\/uploads\/2018\/11\/1.1-degradado-fondo-sec-1-1920x500_Mesa-de-trabajo-1-1.png?id=5054) !important;background-position: 0 0 !important;background-repeat: no-repeat !important;border-radius: 35px !important;}”][vc_widget_sidebar sidebar_id=”grve-default-sidebar”][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"

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